Studies on DLBCL have shown that AKT and mTOR, separately or in combination, regulate transcription and/or translation of MCL-1.25, 26, 27 Exploring AKT activity in our experimental system revealed that p-AKT levels were upregulated 1.9-fold in SU-DHL-6 ABT199-R and 1.8-fold in OCL-LY-19 ABT199-R cells (Figure 1e). Here, MCL1 is linked to diffuse large B-cell lymphoma.