Among those 48 genes present in the ‘axon guidance' family (Supplementary Figure 1D), we observed two members (ROBO1 and SLIT2) of a well-known axon guidance axis, the SLIT/ROBO signaling pathway, recently associated with pancreatic cancer genome aberration and patient survival.10 Moreover, SLIT2 is one of the most overexpressed genes among ‘axon guidance' genes, with a 13.9-fold increased expression (Supplementary Figure 1D). Here, SLIT2 is linked to familial pancreatic carcinoma.