The data support previous work from our group showing that induction of eIF2αP in human tumor cells expressing a conditionally active form of PKR resulted in Akt activation as a means to protect cells from death.33, 34 In addition, PERK activation and increased eIF2αP by ER stress resulted in the induction of the PI3K-Akt pathway to promote cell survival.33, 34 However, it is important to emphasize that, in addition to its ability to activate Akt, eIF2αP is also under regulation by activated Akt. Here, EIF2AK3 is linked to neoplasm.