However, further molecular and interventional studies are required to identify the interacting protein partners of FMRP in the nuclei to establish the exact role of FMRP in DNA repair, regulation of DDR pathway and maintenance of genomic DNA sequence integrity and to determine whether the loss of FMRP function contributes to aberrant activation of the DDR pathway and neurodegeneration in fragile X syndrome. Here, FMR1 is linked to fragile X syndrome.