Interestingly, PSCM3IP or EPSTI1 depletion in breast cancer cells show increased DNA fragmentation and reduced cell viability even in the absence of apoptotic stimuli, indicating that they might also modulate the apoptotic pathway trough alternative mechanisms, such as by BCAR3 or AKT1 interaction, particularly in case of EPSTI1. The gene discussed is EPSTI1; the disease is breast cancer.