As Tfh and antibody responses are thought to contribute to the late control of persistent LCMV infection [32], this effect of GITR on Tfh and Tfr likely impacts the late control of the infection rather than the early control, when Tfh and anti-LCMV IgG levels are comparable between GITR+/+ and GITR-/- mice. The gene discussed is TFRC; the disease is infection.