Interestingly, different chromosomal aberrations affect its locus, carrying to the translation of chimeric proteins, such as PAX2-NCOA2 involved in rhabdosarcoma [38], HEY1-NCOA2 in chondrosarcoma [39], or the first identified MOZ-NCOA2 in acute myeloid leukemia [40]. This evidence concerns the gene HEY1 and chondrosarcoma.