Recently, a tumor microenvironment macrophage inhibitory factor was found to promote accumulation of interleukin-17-producing tumor-infiltrating lymphocytes along with production of high levels of IL-6, IL-8, CD154+, granulocyte-colony stimulating factor (G-CSF) and chemokine (C–X–C motif) ligand 1 (CXCL1) [36]. This evidence concerns the gene CXCL8 and neoplasm.