We found significantly increased granzyme B concentrations in TB-IRIS patients (median, 1617 pg/ml; IQR, 826.5–5227) compared with non-IRIS controls (median, 332.5 pg/ml; IQR, 42.50–1486; p = 0.002; Fig. 4A) and compared with unstimulated cultures. Here, GZMB is linked to tuberculosis.