MMP7 and lung cancer: However, Figure 2 also suggested MMP-7 protein expression in lung cancer patients with histologic grade 3 to 4 (3: moderately differentiated; 4: highly differentiated) was lower than that in patients with histologic grade 1 to 2 (1: undifferentiated; 2: poorly differentiated) (OR = 1.67, 95% CI: 1.14 to 2.42, P = 0.008).