Thus, we conclude that MMP-7 overexpression is tightly linked with the TMN stages, histologic grade and LN metastasis of lung cancer, due to its direct ability for ECM degradation, tissue remodeling and tumor cell proliferation, and also indirectly influence lung cancer metastasis by the abnormal activation of the Wnt signaling pathway and the accumulation of β-catenin. Here, MMP7 is linked to lung cancer.