Depending on the type of macrophages as M1 or M2, tumor survival and resistance progression might be enhanced.87 As supporting evidence, coincubation with a CCL2–antibody enhanced in vitro cell sensitivity to temozolomide, an oral alkylating agent, whereas recombinant CCL2 activated JNK in human melanoma cells and allowed for survival. The gene discussed is CCL2; the disease is neoplasm.