NFKB1 and neoplasm: To the contrary, however, new data have indicated that activated NF-κB components promote the sensitivity of cancer cells to agents that induce apoptosis and senescence, thus restraining tumorigenesis.115,116 As supporting evidence, canonical NF-κB is a Fas transcription activator though the alternative NF-κB is a Fas transcription repressor.117 Therefore, NF-κB promotes Fas-mediated cancer cell apoptosis, while undue inhibition of NF-κB may affect Fas-mediated pathway of cell death, eventually interrupting tumor regression mediated by the host immune system.