MTOR and neoplasm: Another recent study demonstrated that p62 expression is reduced in the stroma of several malignancies and particularly, such stromal loss of p62 caused increased prostate epithelial carcinogenesis.91 The mechanism, of note, implicates cellular redox regulation through a mammalian target of rapamycin (mTOR) C1/c-Myc pathway of stromal metabolism of nutrients including glucose and amino acid, resulting in elevated stromal cytokine IL-6 production, thereby accelerating tumor progression in the epithelial compartment.