Type I interferons (IFNs α and β) are known to drive the expression of ISGs that encode proteins that possess anti-viral, anti-proliferative, pro-apoptotic and pro-inflammatory functions; however, many experimental data have shown that high expression of IFN-induced genes, including STAT1 itself, promotes tumor growth, metastasis and resistance to chemotherapy and radiation [23,44,46,47]. The gene discussed is STAT1; the disease is neoplasm.