To determine the functional significance of IFITM1 and PLSCR1 in AI-resistant MCF-7:5C breast cancer cells, we transiently transfected MCF-7:5C cells with siRNA targeting IFITM1 or PLSCR1 and we assessed the effect of their knockdown on cell proliferation, cell death and cell cycle progression. This evidence concerns the gene IFITM1 and breast cancer.