PLSCR1 and breast carcinoma: To determine the functional significance of IFITM1 and PLSCR1 in AI-resistant MCF-7:5C breast cancer cells, we transiently transfected MCF-7:5C cells with siRNA targeting IFITM1 or PLSCR1 and we assessed the effect of their knockdown on cell proliferation, cell death and cell cycle progression.