Similarly, Pardo et al. [5] reported that in 145 female patients, including anorexia nervosa patients, obese patients, and healthy normal weight subjects, the plasma irisin levels are significantly elevated in the obese patients compared with the anorexia nervosa patients and normal weight subjects, and irisin also positively correlated with body weight, BMI, and fat mass. The gene discussed is FNDC5; the disease is anorexia nervosa.