Pin1 has been implicated in colorectal cancer (β-catenin), breast cancer (Cyclin D, AP-1, Akt, centrosome duplication, Notch1), prostate cancer (TRK-fused gene [TFG]), glioblastoma (NF-κB), hepatocellular carcinoma (HCC, p70S6K, β-catenin) and acute myeloid leukemia (AML, AP-1) [134,135,142,143,144,145,147,148,149,150,151,152]. Here, JUN is linked to Familial prostate cancer.