TIMP3 and cutaneous melanoma: While over-expression of TIMP3 in cell lines derived from cutaneous melanoma metastases has been shown to decrease invasion in vitro [34], this study represents the first time a miR-induced decrease in TIMP3 has been shown to confer an invasive phenotype on a cell line originating from a primary radial growth melanoma WM1552c, a form of melanoma that normally lacks the capacity to invade and metastasize.