BGLAP and hepatocellular carcinoma: The present results revealed that the HH and Hh genotypes of the rs1800247 (HindIII) site in the osteocalcin gene were associated with a significantly increased susceptibility to HBV-related HCC compared with the hh genotype after adjustment for age, sex, smoking status, and alcohol consumption (OR = 6.828, 95% CI 2.620–17.795, P< 0.001; OR = 6.306, 95% CI 3.480–11.423, P< 0.001, respectively).