The object of the present study is, for the first time, to determine whether osteocalcin gene rs1800247 (HindIII) and rs1543297 polymorphisms are associated with the susceptibility to chronic Hepatitis B (CHB), HBV-related liver cirrhosis (LC), and HBV-related HCC in a Chinese population. The gene discussed is BGLAP; the disease is hepatocellular carcinoma.