The mean serum osteocalcin concentration in healthy controls, CHB patients, LC patients, and HCC patients was 15.3±6.06 ng/mL, 13.3±8.38 ng/mL, 14.57±9.53 ng/mL, and 11.73±8.180 ng/mL, respectively. This evidence concerns the gene BGLAP and hepatocellular carcinoma.