NLRP3 and type 2 diabetes mellitus: More data on the interactions between ACE I/D polymorphism and ARB therapy have been provided by analyses of the Reduction of Endpoints in NIDDM with the AII Antagonist Losartan (RENAAL) study, a double blind, multicenter, prospective, randomized, and placebo controlled clinical trial designed to evaluate the renal effects of losartan in 1513 type 2 diabetic patients with overt nephropathy [53].