On the other hand, there are also data indicating no major effect of IL12B on type 1 DM susceptibility in the entire study group [46], no association of IL4R with type 1 DM [47], no evident causal relationship between vitamin D pathway genes and type 2 DM, myocardial infarction or mortality [48], similar distribution of genotypes, allele and haplotypes of VDR rs2228570 and VDR rs731236 between type 2 DM patients and controls [49], no contribution of VDR rs1544410 to type 1 DM susceptibility [50], and no association of VDR rs1544410 with chronic kidney disease susceptibility [51]. This evidence concerns the gene IL4R and chronic kidney disease.