IRS1 and neoplasm: The most significant protein elevations in tumor were checkpoint kinase p-Chk 1 (Ser 345), p-Chk (Ser33/35), eukarytotic translation initiation factor 4E-binding protein 1 p-4E-BP1 (Ser65), protein kinase C p-PKC zeta/iota (Thr410/T412), p-LKB1 (Ser334), inhibitor of kappaB alpha p-IkB-α (Ser32), eukaryotic translation initiation factor4E p-eIF4E (Ser209), p-Smad2 (Ser465/67), insulin receptor substrate 1 p-IRS-1 (Ser612), p-MEK1/2 (Ser217/221), and total PKC iota [111].