In addition, a set of 15 candidate genes was tested for methylation status in HNSCC patients, of which CDH1, p16, DAPK, hMLH1, MGMT, MST1, RARβ, RASSF2, RASSF5 were more significantly hypermethylated on the promoters in tumors than matched normal mucosal tissues [71]. The gene discussed is MGMT; the disease is head and neck squamous cell carcinoma.