Myocardial hypertrophy is commonly caused by hypertension, vascular disease of the heart, coronary heart disease, myocardial infarction and congenital heart disease etc. In recent years, the experts have thought highly of the imbalance of neurohumor factors such as catecholamine, endothelin-1, various growth factors, especially the renin-angiotensin-aldosterone system that causes myocardial hypertrophy. The gene discussed is EDN1; the disease is cardiac hypertrophy.