The aim of the current study was to analyze the relationship of the APOA5 p.S19W, APOB p.E4181K, FABP2 p.A55T, LDLR c.1959C>T, LIPC −514 C>T, LPL p.S474X, and MTTP −493 G>T polymorphisms with blood pressure and lipid levels in Mexican HT patients and in subgroups classified according to the presentation of different dyslipidemias. This evidence concerns the gene APOA5 and hematocrit.