Moreover, it is important to specify that the residual p53 transcriptional activity in our primary B-CLL samples harboring mutations affecting the hot spot region [273-280 aa] could not be ascribed to low frequency of the TP53 mutation, since it was observed also in patient samples in which the mutation frequency was >90% (Table 2). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.