As shown in Figure 4A, the induction of CDKN1A/p21, MDM2, BAX was comparable among the control group of B-CLL samples, which did not harbor any of the analyzed mutations, and the B-CLL samples characterized by either ATM mutations (n=18) or NOTCH1 mutations (n=10). This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.