When neutrophils were recruited to peritoneal cavity with CXCL1-expressing cells (C-PC, non-inflammatory) [7], the neutrophils from tumor-bearing mice and pG/pI6-mice showed a protumor phenotype, characterized by higher expression of Bv8 and Mmp9 as well as lower expression of Rab27a and Trail [7]. This evidence concerns the gene PROK2 and neoplasm.