HIF1A and triple-negative breast carcinoma: In orthotopic mouse models of triple negative breast cancer, drugs that block HIF-1α accumulation inhibit primary tumor growth and vascularization, local tissue invasion, regional lymph node metastasis, and lung metastasis, as well as reducing the percentage of BCSCs in the primary tumor [20, 21, 47], suggesting that co-administration of a HIF-1 inhibitor with chemotherapy may improve outcome in this patient population.