The poor colocalization of LAMP2A with the SNARE VAMP7 in Ctns−/− cells compared to wild-type cells (Fig6B) raises the question of whether the VAMP7-dependent transport of LAMP2A is defective in cystinosis, and suggests that further examination of the VAMP7-dependent transport system in cystinosis would be necessary to further elucidate this question. The gene discussed is VAMP7; the disease is cystinosis.