GFAP and hypertensive disorder: SHRSP gene expression differences at 5 weeks of age were more numerous than at 16 or 21 weeks of age and included downregulation of Mmp14, Mbp, GFAP, AVP, Alb, and Igf2, upregulation of Gucy1A3, Rps9, Fos, and JunB, early-growth response, cell-signaling genes, and overexpression of genes involved in neurological diseases (stroke, depression, and blood–brain barrier leakage),14 rather than just hypertension.