WMH in old age are known associates of late-onset depression,41 and they are also associated with lower age 11 IQ.42MRPL18 is the mitochondrial ribosomal protein L18, previously associated with multiple sclerosis.43 These 7 SHRSP-derived genes are related to pathologies (ataxia telangiectasia, blood–brain barrier impairment, Alzheimer's disease, multiple sclerosis, depression, developmental intellectual disabilities, and brain size) that display white matter abnormalities or affect intellectual function. Here, MRPL18 is linked to major depressive disorder.