However, differences in protein and gene expression in SHRSP rats versus WKY rats at 5 weeks of age (before measurable blood pressure rises) suggest underlying susceptibilities to SVD.13 Compared with WKY controls, 5-week-old SHRSP rats have reduced claudin 5 (tight junction) and myelin basic protein and increased microglia (IBA1) and glial activation (GFAP)13; at 16 and 21 weeks, increase in smooth muscle actin was seen, thought to reflect arteriolar smooth muscle hyperplasia secondary to hypertension. This evidence concerns the gene MBP and hypertensive disorder.