In multivariate analysis, MF/MC cancers were independent prognostic factors for poorer BCSS together with higher number of metastatic axillary lymphnodes, absence of oestrogen receptors and high proliferative activity as expressed by Mib-1 staining (Table 5).MF and MC cancers were related to a significantly shorter BCSS in patients submitted to mastectomy as well as those submitted to conservative surgery (Figures 1 and 2). This evidence concerns the gene MIB1 and cancer.