Based on locus and integration-specific PCR, infection of RPE cells with only Cdk2-SN-T160A-NeoR rAAV (no CRIPSR) resulted in 1/19 (5%) NeoR colonies containing recombined Cdk2-SN-T160A single alleles, and no double alleles (Figure 3A) (Supplementary Figure S2I). The gene discussed is CDK2; the disease is infection.