Genome-wide scans of linkage in hereditary prostate cancer families have demonstrated that the chromosomal region for AMACR (5p13) is the location of a prostate cancer susceptibility gene [9,10] and AMACR gene sequence variants (polymorphisms) have been shown to co-segregate with cancer of the prostate in families with hereditary prostate cancer [7]. The gene discussed is AMACR; the disease is prostate cancer, hereditary.