Secondary models investigating for APOE ɛ4 specific associations by testing for interactions between analytes and the APOE ɛ4 allele indicated that the association of 29 analytes with AD seemed to be modified for the APOE ɛ4 at P-value <0.05; However, none of these associations were significant at q-value <0.05 (results not presented). This evidence concerns the gene APOE and Alzheimer disease.