SPHK1 and colonic neoplasm: In addition, lots of highly reported gastric biomarkers such asReg IV (138, 139), serum amyloid A (SAA) (140, 141), Adipocytokine (142, 143),  sphingosine kinase 1 (SK1) (144, 145), and SM22 (146, 147) were observed during this review, but all of them were correlated with colon cancer as well.