To correlate these data to FOXO3a expression, tissue microarrays consisted of normal/cancer adjacent (n = 66), DCIS (n = 167), invasive (n = 179) and metastatic (n = 99) samples were immunohistochemically stained with anti-BRCA1-IRIS, -survivin and -FOXO3a antibodies. Here, BRCA1 is linked to cancer.