CRF antagonists injected intracerebroventricularly or systemically also block the potentiated anxiety-like responses to stressors observed during protracted abstinence from chronic ethanol (Breese et al., 2005; Valdez et al., 2003; Huang et al., 2010; Overstreet et al., 2007; Wills et al., 2009). Here, CRH is linked to Anxiety.