Exendin-4 and GLP-1 decreased RAGE levels in AGEs-exposed human retinal pigment epithelial cells and made these cells more resistant to harmful effects of AGEs, leading to suppression of ICAM-1 and VCAM-1 levels [152], thus suggesting the clinical utility of DPP-4 inhibitors and/or GLP-1-based medicine for the treatment of obese type 2 diabetes, including diabetic retinopathy. This evidence concerns the gene GCG and diabetic retinopathy.