SEPT4, expressed exclusively in quiescent HSCs in mouse and human liver [15,16], is down-regulated during myofibroblastic transformation of mouse HSCs in vitro, and that genetic loss of mouse Sept4 consistently augments liver fibrosis in CCl4, BDL and MCD diet models of liver diseases, indicating that SEPT4 is involved in suppressive regulation of myofibroblastic transformation and fibrogenesis in liver fibrosis [15]. This evidence concerns the gene SEPTIN4 and liver disorder.