Given that the pro-inflammatory cytokines are closely associated with schistosome egg granuloma formation in the acute stage of schistosome egg-induced liver fibrosis [24], and the granulomatous inflammatory process induces activation of HSCs [25], we wonder if the inflammation caused by the infection of S. japonicum can cause the up-regulation of SEPT4 in the mouse model of S. japonicum egg-induced liver fibrosis. This evidence concerns the gene SEPTIN4 and infection.