Other involved mechanisms include increased myocardial interstitial fibrosis [30], activation of sympathetic nervous system [31], increased afterload and impaired ventricular-vascular coupling due to arterial stiffness [32,33], endothelial dysfunction [34], increased myocardial oxidative stress [35] or secretion of fatty acid-binding protein 4 [36]. Here, FABP4 is linked to endothelial dysfunction.