VDR and neurodegenerative disease: In a study of the US general population, adults aged 60 years and older with the VDR rs2239185–rs731236 (Taq1) CC haplotype showed a negative association between blood lead and serum homocysteine, a risk factor of CVD and neurodegenerative disease, while those with the VDR rs2239185–rs731236 CT or TT showed a positive association[23].