Gene expression profiles of 84 key genes involved in the regulated degradation of cellular proteins by the ubiquitin-proteasome system (Figure 1A) were performed in PBMCs from six each of: sporadic FTD patients, C9ORF72 expansion carriers, GRN Thr272fs (g.1977_1980delCACT) carriers, and age-matched healthy control groups. This evidence concerns the gene GRN and frontotemporal dementia.