Some genetic polymorphisms (such as A163G, T245G, T950C, G1181C, g.18861A>G, and g.27406C>T) in OPG gene have been reported to play genetic influence on BMD and osteoporosis [6, 7, 9, 10, 16, 18, 22, 25–32]. The gene discussed is TNFRSF11B; the disease is osteoporosis.