LRP5 and osteoporosis: In the ethnicity-stratified subgroups, we found that the LRP5 rs3736228 C>T polymorphism-containing populations were more likely to develop osteoporosis and fractures in the Caucasians under both the allele and dominant models (T allele versus C: OR = 1.42, 95% CI = 1.04~1.95, and P = 0.027; CT + TT versus CC: OR = 1.56, 95% CI = 1.08~2.25, and P = 0.018), yet similar results were not observed among Asians (P > 0.05) (as shown in Figure 3).