Results in this meta-analysis demonstrated that the carriers of the rs3736228 C>T polymorphism in the LRP5 gene were associated with an increased risk of developing osteoporosis and fractures in the allele model, whereas the dominant model of LRP5 rs3736228 C>T showed no statistically significant differences between the cases and controls derived from the 7 included studies (OR = 1.19, 95% CI = 0.97~1.46, and P = 0.103) (Figure 2). This evidence concerns the gene LRP5 and osteoporosis.