CETP and hyperlipidemia: Generally, during postprandial lipemia, the cholesteryl ester transfer protein- (CETP-, glycoprotein secreted mainly from the liver) mediated transfer of cholesteryl esters and TGs between plasma lipoprotein particles is increased, allowing transformation of cholesteryl ester-enriched HDL into TG-rich HDL particles which become a substrate for hepatic lipase and are cleared more rapidly from the circulation.