The primary causes of SEHTG are rare (<10% of cases) and often monogenic in etiology and frequently cause pancreatitis such as familial chylomicronemia, LPL deficiency, familial apolipoprotein (apo) C-II deficiency, and primary hyperlipemia type V. Secondary causes include DMT2, MetS, chronic renal failure, nephrotic syndrome, hypothyroidism, pregnancy, excess alcohol intake, and medications such as corticosteroids, estrogens, retinoids, diuretics, and antiretroviral therapy. This evidence concerns the gene APOC2 and hyperinsulinemic hypoglycemia, familial, 4.