SNCA and Parkinson disease: Morphological and structural differences have been noted inpatients with Lewy bodies consistent with the concept of different α-synucleinstrains – Lewy bodies in the brainstem are morphologically different from those inthe cortex [55], and conformationally differentstrains of α-synuclein have been identified from cortical tissue samples ofpatients with PD depending on the presence or absence of Alzheimer pathologies[52].