BCHE and Lewy body dementia: Their effect in DLB is less clear[115], potentially because DLB is poorlydiagnosed clinically and often has multiple underlying pathologies (see above).Interestingly, successful treatment with cholinesterase inhibitors was shown to decreaseβ-amyloid deposition in a small study of DLB patients [116], suggesting that these drugs have mechanistic as well assymptomatic effects.