SNCA and Alzheimer disease: It is clear for Lewy bodydisorders that the neuronal propagation can be slow or rapid, and is impacted on by ADpathology; however, Lewy bodies in AD are focused in the amygdala, suggesting that theinitiating region of α-synuclein aggregation in the brain can be diverse.Importantly, the concept of propagation of α-synuclein pathology between neuronshas resulted in the development of new therapies that target this mechanism with thepotential to halt or slow this aspect of Lewy body diseases.