Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized bythe accumulation of hyperphosphorylated tau protein (p-tau) in neurons and astrocytes ina pattern that is unique from that of other tauopathies, including Alzheimer’sdisease (AD) and frontotemporal lobar degeneration. The gene discussed is MAPT; the disease is Alzheimer disease.