However it should be noted that ACTH-dependence of aldosterone secretion has been noted without such genetic abnormalities [35], while it has been also reported in patients with 11-hydroxylase defects [8–10, 12, 21] and is characteristic of PA-adenoma [3] and it is extremely unlikely that both those conditions would also present that genetic defect. The gene discussed is POMC; the disease is adenoma.