In this report we found that ACTH-dependent aldosterone secretion is very common in EHBP or at least in the highly selected group of the patients such as this one but furthermore characterizes patients with disordered steroidogenesis, 11-hydroxylase and 21-hydroxylase defects, patients with PA either hyperplasia or adenoma, and patients with HBP secondary to renal diseases. The gene discussed is POMC; the disease is adenoma.