In 2009, Dear and his colleagues [82] demonstrated in cecal ligation and puncture (CLP) induced organ dysfunction by difference in-gel electrophoresis (DIGE) that cyclophilins including CyPA increased in abundance after CLP and sepsis-induced renal dysfunction was significantly attenuated after CD147, the receptor for CyPA, was inhibited by anti-CD147 antibody intraperitoneally. Here, PPIA is linked to Abnormal renal physiology.