Among the most significant cases we found KIF1B, which has been implicated in apoptosis (39); ATP1A1, proposed to have tumor suppressor activity (40); ITGA6, found to be required for the growth and survival of a stem cell like subpopulation of MCF7 cells (41); and CTNND1, whose alternative splicing was previously related to cell invasion and metastasis (42) (Figure 4A). This evidence concerns the gene ITGA6 and neoplasm.