In particular, the tumor drivers PPARG, CCND3, RALGDS, MITF, PRDM1, ABI1 and MYH11, present recurrent isoform switches in LUSC, BRCA, KIRC, KIRC, LUSC, LUSC and COAD, respectively, which affect the encoded proteins and which could have implications for the identification of possible targeted therapies. The gene discussed is MYH11; the disease is neoplasm.