In addition, significantly reduced expression of filamin C was detected in 5 datasets of colon cancers (510 cases), 3 datasets of breast cancer (2,564 cases), 3 datasets of bladder cancer (282 cases), 4 datasets of head-neck cancers (95 cases), 1 dataset of leukemia (2,022 cases), 3 datasets of ovarian cancer (674 cases), 1 dataset of esophagus cancer (53 cases), and 4 datasets of lung cancer (410 cases) (Supplementary Figure 3). The gene discussed is FLNC; the disease is esophageal cancer.