Recent exome sequencing have also identified that genes encoding the tumor protein p53 (TP53), phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha, AT rich interactive domain 1A, activin receptor type 2, ribosomal protein L22, and lectin, mannose-binding, 1 (LMAN1) were frequently mutated in GC patients [6–8]. The gene discussed is TP53; the disease is gastric cancer.