In attempts to find molecules regulating aggressiveness of BRAFV600E melanoma cells, by whole-genome array we found that SEMA6A and MICAL1, two genes of the SEMA/PLEXIN signaling pathway, were over-expressed in BRAFV600E clones compared to NRASQ61R clones isolated from the same metastasis. This evidence concerns the gene SEMA6A and melanoma.