Mice were sacrified after 21 days due excessive tumour growth in vehicle treated mice; at this time PJ34 continued to be effective as anti-tumour agent indicating that the combined inhibition of a pro-survival pathway (using erlotinib) together with the inactivation of HR and the induction of genomic instability by PARP inhibition has a synergic in vivo anti-tumour effect. This evidence concerns the gene PARP1 and neoplasm.