To test whether the expression levels of PKM2 and TRIM35 were independent of other predictive variables, we applied univariate and multivariate analyses using a Cox multivariate proportional hazard regression model with PKM2/TRIM35 expression and clinicopathologic factors (such as age, gender, tumor size, vascular invasion, and stage) as covariates. The gene discussed is TRIM35; the disease is neoplasm.